THE PD-(D/E)XK SUPERFAMILY REVISITED: IDENTIFICATION OF NEW MEMBERS AMONG PROTEINS INVOLVED IN DNA METABOLISM AND FUNCTIONAL PREDICTIONS FOR DOMAINS OF (HITHERTO) UNKNOWN FUNCTION

Abstract Background The PD-(D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and repair, is one of the most challenging targets for protein sequence analysis and structure prediction.Typically, the sequence similarity between these proteins is so low, that

We deploy and demonstrate the CoinTossX low-latency, high-throughput, open-source matching engine through small-scale desktop and large-scale locally-hosted testing with multiple traded instruments and clients managed concurrently by sending orders using the Julia and Python languages.We demonstrate a cloud-based deployment using Microsoft Azure, w

As main health service providers in primary care, read more general practitioners (GPs) undertake the responsibility of gatekeepers for residents' health.Vigorously training GPs will contribute to the transformation of the healthcare delivery model, and the addressing of the issue related to difficult and high cost of getting medical treatment